To talk someone's head off:
Hablar sin parar / Cansar a alguien con charlas interminables.
Ejemplos:
Why does John always talk his head off? Doesn't he know he bores people?
She talks her head off and doesn't seem to know what she's saying.
John is very friendly, but watch out or he'll talk your head off.
My uncle always talked my head off whenever I went to visit him.
Significado del diccionario inglés-español:
Head off – desviarse, adelantarse para desviar, rechazar, impedir, obstruir el camino de, fig. prevenir, obstaculizar.
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